The pop icon's family has spoken of "unanswered questions" concerning Murray's role in the final hours of Jackson's life. Murray's lawyers insist he has been cleared of wrongdoing.
TMZ, citing "multiple" law enforcement sources, said "the evidence points to the anaesthesia Propofol as the primary cause of Jackson's death."
Law enforcement sources told TMZ there was already "plenty of powerful evidence" pointing to Murray, 51, as the person who administered the drug, whose brand name is Diprivan, to the "King of Pop."
The evidence, TMZ said, includes items found in Jackson's rented mansion, including Propofol, an IV stand and an oxygen tank.
The drug is used to induce unconsciousness in hospital patients ahead of major surgery and experts say it should only be administered by a trained anaesthesiologist.
The LAPD has already had "multiple conversations with the Los Angeles County District Attorney's office, even though the case has not yet been formally presented to the district attorney, the celebrity website said.
The report came after the Los Angeles County Coroner's office subpoenaed the superstar's dermatologist Arnold Klein on Tuesday, seeking "additional medical records" from the physician's Beverly Hills office.
Investigators have been scrutinizing the possible role of drugs in the death of Jackson.
Copyright AFP (Agence France-Presse), 2009
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